The IeDEA Tuberculosis SRN (TB-SRN) is a prospective observational study that will enroll individuals diagnosed with presumptive or confirmed active pulmonary tuberculosis (TB). The TB-SRN will enroll both people living with HIV (PLWH) and HIV-negative adults (>18 years) to assess the effect of HIV on post-treatment pulmonary function and the incidence and predictors of recurrent TB. Using a common set of standards and definitions for prospective observational TB research aligned with the data framework developed by the Regional Prospective Observational Research in Tuberculosis (RePORT) International Consortium, the TB-SRN will provide pooled data to improve understanding of TB outcomes, survival, recurrence and to assess the patient-level effects of HIV and antiretroviral therapy (ART) on TB symptomatology, diagnosis, treatment response, and survival.
Within CA-IeDEA, in addition to collecting the standard TB-SRN data, we will leverage the TB-SRN platform to address specific regional aims:
- To determine the effect of HIV on post-treatment lung function impairment among patients treated for pulmonary TB;
- To determine the incidence of post-treatment TB recurrence and determinants (e.g. tobacco smoking, diabetes, HIV) among patients treated for pulmonary TB;
- To leverage the CA-IeDEA partnership with National Tuberculosis Program and academic institutions to build capacity and fast track development and pilot implementation of new rapid diagnosis tools.
Located in Kinshasa, DRC, the CA-IeDEA TB-SRN site plans to enroll 450 individuals diagnosed with presumptive or confirmed active pulmonary TB participants over a three-year period, following each through the end of all treatment and for 12 months after the completion of treatment.